Human microbiome. Possibilities for diagnostics and nutritional correction - course 80,000 rubles. from the University of Educational Medicine, training 155 academic hours of theory, Date: November 29, 2023.
Miscellaneous / / December 01, 2023
Our heredity, diagnoses or life circumstances remain, but the microbiome is the most changeable plastic organ of our body, we can actually use the help of hundreds of trillions of microbes each day.
Despite the volume of the topic, the lectures are easy to understand and all the material is structured methodologically from simple to complex, and intermodular activities allow you to practice mastering practical topics (analysis and reading popular science texts) with feedback from the team course.
MODULE 1
Basic understanding of microbiota.
Introduction to the microbiome. Who are microbes? History of microbiome research. The role of the microbiome in infectious and chronic diseases. A look at the microbiome from an evolutionary perspective. The cutting edge of today's microbiome science.
Introduction to microbiology. Introduction to the bacterial kingdom. Types, genera and strains of bacteria. Main bacterial genera and their functions. Structural and functional features of bacteria that allow the creation of testing technologies. Emergence of resistance in bacteria. Conditionally pathogenic microbes.
Microbiome and immunity. Principles of interaction between the immune system and the microbiome. Acquired and innate immune responses to the microbiome. Microbiome-induced inflammatory disorders. Localization of inflammatory processes, systemic and chronic inflammation. Statistics of chronic inflammation and major age-related diseases. Inflammation, stress and the microbiome. The role of the microbiome in neuroendocrine regulation. Immune system dysfunctions and the microbiome's potential for correction. Immunization and the microbiome.
Digestive functions and microbiome. Mucosal enzymes and processes in the microbiome. Formation of secondary FAs and their regulation. The role of the liver and bile in the functioning of the microbiome. Disorders of bile metabolism and pancreatic enzymes. Detoxification processes in the liver and the role of the microbiome. Violations of acidity and balance of macro- and micronutrients. Disorders of intestinal physiology (sphincter and motility), lactose intolerance, gluten intolerance, histamine intolerance. Formation of secondary bile acids. The role of nutrition as a substrate for intestinal function. The role of individual microbes in the biochemistry of enzymes and bile. Consequences and identification of micro- and macronutrient imbalances.
Theory and review of diagnostic methods. Relevance of microbiota tests, what do they actually measure? Pros, cons and applicability of approaches, Osipov tests, tests for exopolysaccharides and endotoxemia, permeability tests (zonulin, calprotectin), breath tests, coprogram. Microbiota genetics and tests based on measuring DNA and RNA of microbes. The difference between medical tests and recreational ones. Determining the quality of microbiota through questionnaires and a food diary.
MODULE 2
Interventions and the microbiome.
Diets and micro/macro nutrients. Microbially available carbohydrates. Fibers. Protein compounds. Protein compounds like fibers. Fermentation and rotting. Metabolism of fats by microbes. Minerals and microbiome, causes of major deficiencies and indigestibility. Polyphenolic compounds and the degree of their availability in different microbiome configurations.
Types of microbes: good and bad. Pathogens and opportunistic microbes: bacteria, viruses and fungi. Scientifically proven “beneficial microbes” for weight loss and anti-inflammatory. Principles of mutualism and commensalism. Balance of microflora representatives. The basis for modulating balance using nutrition and dietary supplements. Functional portrait of the microbiome.
Major risk factors created by the microbiome. Induced immune response, dysbiosis, disruption of the mucous membrane and the functions of parietal digestion. Systemic influence of exopolysaccharides and endotoxemia. Insulin resistance and glycation level. Hyperlipidemia and disruption of the third phase of detoxification.
Probiotics. Basis for creating probiotic products. Sources of strains for probiotics. Technologies for the production of probiotics - dry and wet. Means of delivering probiotics to the intestines. Reviews key research and benefit claims from an evidence-based medicine perspective. Map of probiotics market in Russia and abroad. Prospects for new probiotic strains. Multicomponent probiotics. How to read the ingredients on the package.
Prebiotics. Prebiotics and Fiber: What's the Difference? 5 levels of evidence for prebiotics. Dosage and benefits. Prebiotics from plants. Prebiotics from marine cultures. Prebiotics from microorganisms and fungi. Specialized prebiotic complexes with functional load and high biological activity. Map of manufacturers and brands in Russia and abroad.
Meta-, syn- and symbiotics.> Meta-, sym-, and syn- - myth or reality? Current state of research and biological basis for the increased activity of the combinations. Advantages and disadvantages of formulations over traditional pre- and probiotics.
The science behind the benefits of fermentation. History of fermentation. Main fermented products in Russia and in the world. Technological differences in the production of home and industrial fermented foods. Basic research for fermented foods. Scientifically proven properties for sourdough starters, kefir, kombucha, vegetable mixtures and traditional Japanese starters. Fermentation as the basis for creating super formulas for nutrition and recovery. Histamine and fermentation.
MODULE 3
Microbiome and pathologies.
Microbiome and cardiovascular diseases. Atherosclerosis: rheological properties of blood vessels, lipid metabolism and inflammation - their connection with the microbiome. Transition from atherosclerosis to CVD in acute form. Formation of proatherogenic substances using the example of TMAO, prognostic properties of clinical tests. Heart muscle and inflammation. Mucosal film, pathogens and SPKD and the relationship with CVD. Primary and secondary GI and CVD against the background of the microbiome. Uremic toxins, microbiome and pressure (against the background of kidney dysfunction) as a risk of CVD. New markers: circulating microbiota metabolites and their relationship with endothelial function with CVD risk. Promising interventions for CVD risks caused by microbiome dysfunctions. The effect of drugs (not antibiotics) on decreased microbiome function and CVD risks. Anti-TMAO diet. Prescribe nutritional interventions in cases of high risk of CVD events or recurrent events.
Microbiome and metabolic syndrome and diabetes. The role of the microbiome in insulin resistance. Microbiome triggers of the inflammatory process in metabolic syndrome. Immune system receptors that respond to inflammation. The role of peptides in regulating signal transmission from the microbiome to organs and tissues. Impaired gut-brain signaling in the prediabetic state. The connection between glycation and the microbiome, chronic conditions in diabetes and their management. Antiglycemic probiotics. Dietary supplements and pharmaceutical interventions in diabetes and their relationship with the microbiome. Creating nutritional interventions to increase acetate and butyrate pools.
Microbiome and chronic fatigue syndrome. CFS and the symptom complex associated with the microbiome. The role of dysbiosis and associated factors in the etiology of CFS. The gut-brain axis as a point of effort in the prevention of CFS. Psychobiotics. Potential of the microbiome to produce short-chain acids and remission of encephalomyelitis. Prevention of vagal tone from the point of view of an integrative approach.
Microbiome and allergies. The main ways of occurrence of allergies. Food and seasonal allergies are one principle of immunization. Reducing the allergic load and reducing the pro-inflammatory response: what's the difference. Main allergies and main allergens. Possibilities of modern allergen testing. Probiotics against allergies: myths and possibilities.
Microbiome and cancer: prevention, remission. Etiology of major types of cancer and relationship with risk factors provoked by the microbiome. Colon and stomach cancer and the microbiome. Female and male cancers and the microbiome. Focus on the microbiome in chemotherapy and radiation therapy. The role of the microbiome in immunotherapy protocols.
Microbiome and recovery after illness. Recovery after treatment, main complications, incl. mucositis and indigestibility. Maintaining stable remission. Creation of personalized protocols for monitoring the state of the microbiome for people in remission. Periodic microbiome interventions to obtain a hormesis effect in the interaction of the microbiome and the immune system.
Microbiome and autoimmune processes. Causes of major autoimmune disorders, results of microbiome analysis in such disorders. Maintaining long-term remission in autoimmune diseases using microbiome-targeted interventions. The role of the client in microbiome health management in autoimmune diseases. Stress, microbiome and autoimmunity from a functional perspective.
MODULE 4
Microbiome and specificity by gender and age. Advanced Topics
Vaginal microbiome. Fundamentals of vaginal physiology and microbiome. Basic tests and health criteria. Chronic vaginosis and vaginitis as risk factors for women's health and infertility. Vagina-bowel connection; creating personalized plans for sustainable remission. Local probiotics: review of approaches and products on the Russian and foreign markets.
Microbiome and pregnancy. Features of the intestinal and vaginal microbiome by trimester. Formation of a child’s immunity in the womb and supporting factors. Main disorders, risks during pregnancy and microbiome. Safe to use probiotic preparations. Endotoxemia, cholestasis, gestational diabetes and the connection with the microbiome.
Microbiome of the baby and child. The first thousand days in the health of a child and his microbiome. Basic disorders and methods of correction. Improving the quality of breast milk. Working with children after cesarean section. Non-nutritional factors important for the formation of the microbiome. Childhood vaccinations and ways to reduce risk. Attention deficit and autism.
Microbiome and aging. Microbiome during the decline of metabolic potential. Aging as a complex process. Age-related diseases, their comorbidity and ways to reduce risk by working with digestion and mucosal health. Main problems of older people and modification of the microbiome. The concept of fragility in aging and counteraction.
Microbiome and neurodegenerative diseases. Parkinson's, Alzheimer's and multiple sclerosis: current data on occurrence and risk factors. Reducing the rate of development of neurodegenerative diseases. Combination of depression in adulthood with the development of neurodegeneration and microbiome protocols.
Microbiome and the brain. Basic mechanisms of connection between the microbiome and the brain. Neurofitness and opportunities to enhance cognitive function using microbiome knowledge. Self-diagnosis of the connection between the microbiome and the brain. The role of the vagus and the design of diets for vagal tone and reduction of chronic stress.
Microbiome and neuroendocrine regulation. Hypothalamus-pituitary-microbiome axis. Major dysregulation of the axis, associated risks of chronic syndromes. Preventive protocols for working with the axis and protocols for maintaining stable remission.
Skin microbiome. The connection between the skin and the intestinal microbiome. Skin microbiome. Diagnosis of microbiome disorders based on the skin. Major skin diseases and microbiome-oriented recovery protocols. Cosmetics and care products with probiotics.
MODULE 5
Writing a research paper with the support of a mentor
Conducting analysis of scientific reviews in Russian and English languages
Publication in your own social networks and in UOM media