Scientists have confirmed that sand helps to treat obesity
Miscellaneous / / April 04, 2023
New experiments have made it possible to establish exactly how this mechanism works.
New studyThe Anti-Obesity Effect of Porous Silica Is Dependent on Pore Nanostructure, Particle Size, and Surface Chemistry in an In Vitro Digestion Model / Pharmaceutics Scientists from the University of South Australia confirmed the potential of porous silica particles from refined sand to alter the body's absorption of fats and sugars.
Researchers have shown that such particles can affect how the body absorbs energy from foods high in fat.
Porous silica is gaining more and more attention due to its potential to combat obeseand human trials have shown it to be a safe therapy. However, how exactly this works has eluded researchers—until now. Our study shows how porous silica contributes to the fight against obesity by acting locally in the intestine, limiting the digestion and absorption of fats and carbohydrates.
Paul Joyce
lead researcher
The scientist added that the gentle mechanism of interaction with such particles provides clinically effective weight loss results without side effects.
It was previously unclear exactly how mesoporous silica particles might interfere with metabolism, but scientists have hypothesized that they affect the behavior of certain digestive enzymes. To explore this idea in more detail, Joyce and his team developed an improved digestion model. in vitroin vitro ("In vitro"; from lat. - "in glass") - the term and methodology for performing experiments "in a test tube".which allowed them to control the digestion of lipids and carbohydrates while simulating a meal high in fat and carbohydrates.
Experiments have shown that artificial silica particles made from refined sand have their effect against obesity by inhibiting the activity of digestive enzymes called α-amyls and pancreatic lipase in the gastrointestinal tract.
As in previous studies, the scientists found that these effects are strongly influenced by the pore size of the particles themselves. And the best results are given by those in which it is 6-10 nanometers.
The next steps are to confirm these results using animal models of obesity. This will allow us to determine options for optimal conditions for combating this completely preventable disease, the authors of the work noted.
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