Have you ever wondered, what time of day is best to drink coffee? Surely you know that drinking coffee in the afternoon is not a good idea, especially if you have trouble sleeping. But even in the morning you have ever felt that coffee just does not work for you?
The explanation for this can be found in one discipline that is rarely discussed, but this does not become less interesting - chronopharmacology.
Chronopharmacology studies how biological rhythms of the human impact on the effect of drugs. For a person of great importance or the internal circadian clock, which determine the periods of activity and rest for 24 hours (23-25 hours in all mammals).
In addition, these internal, innate rhythms can also affect the medicationTheir safety, effectiveness and even, perhaps, tolerance to them.
But what part of the brain responsible for circadian rhythms, and what signals it uses to comply with a 24-hour work order?
After the reaction was revealed retina and hypothalamus (retinogipotalamusny tract) research, mainly focused on the hypothalamus, as alleged generator of tract.
Several brain research conducted Inoue and Kawamura in 1979 showed that the formation of biological rhythms primarily affects the hypothalamus.
During the experiment, cutting off the hypothalamus from the surrounding tissue, the researchers observed the complete disappearance of the biological clock.
Not only activity but also hormones
hypothalamus cells, and more specifically, suprahiazmalnoe core or the SCN, determines the biological rhythms of the body and has many functions. It controls the waking and sleeping cycle, power and energy consumption, the level of sugar in the body and, among other things, the production of hormones.
For human activity is of particular importance suprahiazmalnogo control over the core level of cortisol, the so-called hormone "stress".
Most of us prefer to have a cup of coffee at 8 am or so, but is it the best time to charge the vivacity of caffeine? The circadian rhythm of cortisol production proves that there is.
How not to "get hooked" on the coffee?
Tolerance to drugs - this is an important topic, and especially of caffeine, because most of us are "sitting" on the coffee.
cortisol is highly dependent on the level of alertness and readiness to meet trouble. It so happened that this time falls on the morning - from 6 to 9 am, and the peak at 8-9 am. Thus, you drink coffee, when the body and so close to the maximum level of vigilance and strength.
One of the key principles of pharmacology - take the medication only when they are needed. Otherwise, the body develops a tolerance to the substance, and you need more and more caffeine.
It seems that the morning coffee did not help, then, to drink another espresso right now.
Although most of cortisol peak between 8 and 9 am, and there are other times in which the amount of this hormone in the blood increases - between noon and 13.00 and between 17.30 and 18.30.
From this perspective, the best effect will be, if you drink coffee from nine-thirty to polodinnadtsatogo morning when cortisol declines until the next spike.
The best effect will be, if you drink coffee from 9.30 to 11.30 am.